JTC 2017 Expression of Interest

Project holder looking for a partner

Main topic(s) of interest : HBP (Basic and Applied Research)

Brief description of project :

The bidirectional signaling between the gastrointestinal tract and the brain, the gut-brain axis, clearly also involves the gut microbiota. Several psychiatric manifestations and neuro-developmental/-degenerative diseases like increased anxiety, depression, autism spectrum disorders, alterations in social behavior, and memory loss disorders are associated with changes in the gut microbiota. However, to date, the mechanisms by which the gut microbiota influence these health conditions are not yet fully understood. Traditional bacterial metabolites such as short chain fatty acids (SCFAs) are being investigated as potential mediators of this gut-brain axis.
We have recently shown by in-vitro studies that quorum sensing peptides, constitutively produced by mainly gram-positive bacteria as inter-bacterial communication molecules, are also able to functionally modify in a selective way the host cells e.g. cancer and brain cells, indicating a causal relationship between microbial produced quorum sensing peptides and the host health.
The global overreaching goal of this research is thus to further elucidate the possible role of quorum sensing peptides as one of the microbiota-related factors in brain disorders by in-vivo animal and human studies.

Keywords : Microbiome; quorum sensing peptides; neuro-psychitric diseases; animal models; translational

Expertise sought : (1) fundamental neurobiology models (eg organoids)


First Name : Bart

Last Name : De Spiegeleer

Country : Belgium

E-mail address : Bart.despiegeleer@ugent.be

Telephone : ++32 9 264 8100

Project holder looking for a partner

Main topic(s) of interest : HBP (Basic and Applied Research)

Brief description of project :

The bidirectional signaling between the gastrointestinal tract and the brain, the gut-brain axis, clearly also involves the gut microbiota. Several psychiatric manifestations and neuro-developmental/-degenerative diseases like increased anxiety, depression, autism spectrum disorders, alterations in social behavior, and memory loss disorders are associated with changes in the gut microbiota. However, to date, the mechanisms by which the gut microbiota influence these health conditions are not yet fully understood. Traditional bacterial metabolites such as short chain fatty acids (SCFAs) are being investigated as potential mediators of this gut-brain axis.
We have recently shown by in-vitro studies that quorum sensing peptides, constitutively produced by mainly gram-positive bacteria as inter-bacterial communication molecules, are also able to functionally modify in a selective way the host cells e.g. cancer and brain cells, indicating a causal relationship between microbial produced quorum sensing peptides and the host health.
The global overreaching goal of this research is thus to further elucidate the possible role of quorum sensing peptides as one of the microbiota-related factors in brain disorders by in-vivo animal and human studies.

Keywords : Microbiome; quorum sensing peptides; neuro-psychitric diseases; animal models; translational

Expertise sought : (1) fundamental neurobiology models (eg organoids) ; (2) animal CNS-disease models ; (3) bioinformatics


First Name : Bart

Last Name : De Spiegeleer

Country : Belgium

E-mail address : Bart.despiegeleer@ugent.be

Telephone : ++32 9 264 8100

Project holder looking for a partner

Main topic(s) of interest : Graphene (Basic Research), Graphene (Applied Research and Innovation), HBP (Basic and Applied Research)

Brief description of project :

I finished a project which Summary is as follow;

Nano- powders based Powder Metallurgy (PM) parts heavily used in the automotive industry, machinery industry, aerospace industry , machine manufacturing, iron and steel industry , dies and molds industry and the defense industry. High- frequency induction sintering method is a rapid prototyping method. If we applied load during sintering of powders, sintering temperature will be decreased. This rapid heating regime in nanostructured materials will to prevent grain growth. Densification will be faster and near to the theoretical density. Within the process, it is possible to gain over 97% of theoretical density by applying pressure. With this method, powders can be pressed and sintered to the desired shape close to the theoretical density. Non oxide ceramic and metal powders must be sintered under vacuum or protective gas due to the tendency for oxidation. Sintering is carried out under the melting temperature of powders representing the matrix composition. Conventional method, cause grain growth in nano sized particles. These phenomena results to decrease hardness and strength. With this work, sintering process will be completed in seconds by applying maximum 35 MPa pressure by the effect of high frequency induction. In this case sintered parts which are densier and having smaller grain sizes can be obtained. Oxidation of the graphite mold and graphane powders will be protected with a vacuum level up to 1X10-3 Torr by using sintering chamber during the experimental studies. As an energy source an induction generator which has 2.8 KW power capacity and 900 kHz high induction frequency will be used. Heating will be generated by magnetic flux spread from induction coil over graphite mold and powders. Under the melting temperature of the ceramic based powders will be sintered by induction at 5-35 MPa pressure under vacuum atmosphere in a minutes. Temperature of the graphite mold will be measured by infrared thermometer from the surface of the mold. This measurement will fix the induction frequency and power of the system. In spite of this measurement, speed of the controlled heating and fixed temperature will determine correctly. Project manager and researchers will be determining the configuration of the vacuum unit, pressing pressure, sintering durations and temperature. After the sintering operation of the ceramic compacts, density and hardness will measure and SEM, EDS, XRD and BET analyses will do. All mechanical properties and analysis will investigate for characterization and properties of the ceramics. With the results obtained for the production of ceramic compacts that provide the best properties will be optimized parameters. The scholarship students will perform high frequency induction sintering process in a vacuum. For characterization and determination of properties of the sintered compacts will done all necessary experimental tests, the effects of the production parameters will investigated for the compacts.

The aim of the project: It is planned to work on the induction sintering of new powders containing nano-graphene.

Dr. Uğur ÇAVDAR

Mechanical Engineer, PhD.
Associate Professor

İDÜ University Industry Cooperation Application and Research Center Director

Vice Director of The Institute of Science

İzmir Demokrasi University, Engineering Faculty, Mechanical Engineering Department

Fax : +90 232 260 1004
Tel : +90 232 260 1001 -Dahili: 503
İzmir Demokrasi University
Üçkuyular Mahallesi,
Gürsel Aksel Bulvarı,
No:14 35140 Karabağlar
İZMİR /TURKEY.

Keywords : Powder Metallurgy, High Frequency Induction Sintering, Nano Technology, Hot Pressing.

Expertise sought : I am looking for; 1) End user 2) Nano graphene provider 3) Nanotechnology mechanical test and nano structure imaging laboratories


First Name : UGUR

Last Name : CAVDAR

Country : Turkey

E-mail address : ugur.cavdar@idu.edu.tr

Telephone : +902322601001

Project holder looking for a partner

Main topic(s) of interest : HBP (Basic and Applied Research)

Brief description of project :

building a migraine model by machine learning, trying to predict effects of treatment, explain failures, and possible re classify migraine patients into sub classes.

Keywords : migraine, machine learning

Expertise sought : migraine expert, machine learning expert


First Name : David

Last Name : Yarnitsky

Country : United States of America

E-mail address : dy@rmc.gov.il

Telephone : +19179600312

Project holder looking for a partner

Main topic(s) of interest : Graphene (Applied Research and Innovation)

Brief description of project :

Perovskites are amazing crystals that affect PV world significantly, that can be thought as a game changer. The power conversion efficiency of perovskite solar cells has reached up to 22% compatible with SiPVs. Perovskite solar cell (PSC) technology is a viable candidate for low-cost large scale production as it is solution processable at low temperature on a flexible substrate.

In this Project we would like to reduce the cost of solar energy and make it competitive with existing renewable sources of energy, new solar cell technologies involving cheaper materials and processing costs need to be made available to the consumers. Perovskite solar cell (PSC) technology has the potential to compete with all the existing renewable sources of energy as it can be solution processed at low temperature on a flexible substrate with very low capital investment.

Graphene has attracted great interest due to its unique electronic, thermal, and mechanical properties, resulting from its two-dimensional (2D) structure, and to its potential applications like solar cells, chemical sensing instruments, biosensors, energy storage devices and other innovations.

In this Project,

 Graphene electrode will be used for perovskite solar cell fabrication.
 Stability and efficiency of perovskite solar cells will be improved with graphene.
 Encapsulation techniques will be developed to increase life time of perovskite solar cell.

Keywords : perovskite solar cell, graphene, stability, encapsulation

Expertise sought : Graphene electrode, barrier layers, perovskite solar cell characterization


First Name : Elif

Last Name : Altürk

Country : Turkey

E-mail address : elif.parlak@tubitak.gov.tr

Telephone : 05537361935

Project holder looking for a partner

Main topic(s) of interest : HBP (Basic and Applied Research)

Brief description of project :

My research interest is to know what makes an antidepressant rapid-acting? Recent research has reported that rapid-acting antidepressant drugs (RAADs) 1) stimulate projections from the prefrontal cortex to the brainstem serotonergic nuclei; 2) need to stimulate cortical AMPA glutamate receptors; 3) use mTOR intracellular signaling and 4) evoke a rapid increase in BDNF synthesis and release.
With this background, we believe that positive allosteric modulators (PAMs) of AMPA receptors may fulfill these conditions and serve as RAADs.

Keywords : serotonin, noradrenaline, dopamine, prefrontal cortex, depression, animal model

Expertise sought : western blotting, in vivo electrophysiology, behavioral assessment, optogenetics, brain circuitry


First Name : Albert

Last Name : Adell

Country : Spain

E-mail address : albert.adell@unican.es

Telephone : (+34) 942 20 68 57